BDBM301077 4-[2-(4-aminopiperidin-1-yl)-5-[2-(1- hydroxycyclopentyl)ethynyl]pyrimidin- 4-yl]benzonitrile::US10131664, Example 70

SMILES: NC1CCN(CC1)c1ncc(C#CC2(O)CCCC2)c(n1)-c1ccc(cc1)C#N

InChI Key: InChIKey=DCPATEPPHROHJR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 301077   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM301077 (4-[2-(4-aminopiperidin-1-yl)-5-[2-(1- hydroxycyclo...) Show SMILES NC1CCN(CC1)c1ncc(C#CC2(O)CCCC2)c(n1)-c1ccc(cc1)C#N Show InChI InChI=1S/C23H25N5O/c24-15-17-3-5-18(6-4-17)21-19(7-12-23(29)10-1-2-11-23)16-26-22(27-21)28-13-8-20(25)9-14-28/h3-6,16,20,29H,1-2,8-11,13-14,25H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...				US Patent US10131664 (2018) BindingDB Entry DOI: 10.7270/Q2JD4ZV1
					More data for this Ligand-Target Pair