BDBM301078 4-[2-(4-aminopiperidin-1-yl)-5-[1- (oxolan-3-yl)pyrazol-4-yl]pyrimidin-4- yl]benzonitrile::US10131664, Example 71

SMILES: NC1CCN(CC1)c1ncc(-c2cnn(c2)C2CCOC2)c(n1)-c1ccc(cc1)C#N

InChI Key: InChIKey=AEYWLPFEYJNKAZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 301078   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM301078 (4-[2-(4-aminopiperidin-1-yl)-5-[1- (oxolan-3-yl)py...) Show SMILES NC1CCN(CC1)c1ncc(-c2cnn(c2)C2CCOC2)c(n1)-c1ccc(cc1)C#N Show InChI InChI=1S/C23H25N7O/c24-11-16-1-3-17(4-2-16)22-21(18-12-27-30(14-18)20-7-10-31-15-20)13-26-23(28-22)29-8-5-19(25)6-9-29/h1-4,12-14,19-20H,5-10,15,25H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...				US Patent US10131664 (2018) BindingDB Entry DOI: 10.7270/Q2JD4ZV1
					More data for this Ligand-Target Pair