BDBM301559 US10131675, Example 45

SMILES: CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cc(c2c1)C(F)(F)F)N1CC(F)C1

InChI Key: InChIKey=JOCNKQWJRKXQFF-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 301559   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM301559 (US10131675, Example 45) Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cc(c2c1)C(F)(F)F)N1CC(F)C1 |$;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;$| Show InChI InChI=1S/C21H19F4N7O/c1-20(2)19-28-14-17(31-8-11(22)9-31)29-15(30-18(14)32(19)3-4-33-20)10-5-12-13(21(23,24)25)7-27-16(12)26-6-10/h5-7,11H,3-4,8-9H2,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.87	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				US Patent US10131675 (2018) BindingDB Entry DOI: 10.7270/Q21G0P92
					More data for this Ligand-Target Pair