BDBM301588 US10131675, Example 74

SMILES: Cc1c[nH]c2ncc(cc12)-c1nc(N2CCC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1

InChI Key: InChIKey=NGBMCVDHGZRNOG-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 301588   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM301588 (US10131675, Example 74) Show SMILES Cc1c[nH]c2ncc(cc12)-c1nc(N2CCC(F)(F)C2)c2nc3n(CCOC3(C)C)c2n1 |$;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;;$| Show InChI InChI=1S/C22H23F2N7O/c1-12-9-25-17-14(12)8-13(10-26-17)16-28-18(30-5-4-22(23,24)11-30)15-19(29-16)31-6-7-32-21(2,3)20(31)27-15/h8-10H,4-7,11H2,1-3H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	25.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				US Patent US10131675 (2018) BindingDB Entry DOI: 10.7270/Q21G0P92
					More data for this Ligand-Target Pair