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SMILES: CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(OC(F)F)c1)C1CC1

InChI Key: InChIKey=DQYCQWJLMBBKEZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 301633   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase kinase kinase 12


(Homo sapiens (Human))		BDBM301633
PNG
(US10131675, Example 119)
Show SMILES CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc(N)c(OC(F)F)c1)C1CC1
Show InChI InChI=1S/C19H20F2N6O2/c1-19(2)17-25-13-12(9-3-4-9)24-15(26-16(13)27(17)5-6-28-19)10-7-11(29-18(20)21)14(22)23-8-10/h7-9,18H,3-6H2,1-2H3,(H2,22,23)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
 34.3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...

US Patent US10131675 (2018)


BindingDB Entry DOI: 10.7270/Q21G0P92
More data for this
Ligand-Target Pair