BDBM301927 US9598396, Compound 4

SMILES: CC(Cc1cccc(c1)C#N)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1

InChI Key:

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 301927   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301927 (US9598396, Compound 4) Show SMILES CC(Cc1cccc(c1)C#N)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301927 (US9598396, Compound 4) Show SMILES CC(Cc1cccc(c1)C#N)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.933	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair