BDBM302889 1-(2-((2S,4R)-2-(6- chloropyridin-2- ylcarbamoyl)-4- fluoropyrrolidin-1-yl)- 2-oxoethyl)-5- (pyrimidin-5- ylamino)-1H- indazole-3- carboxamide::US10660876, Cmpd No. 12::US9598446, Compound 12

SMILES: NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Cl)n2)c2ccc(Nc3cncnc3)cc12

InChI Key: InChIKey=HYNKZTKMOWBTPY-ACJLOTCBSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 302889   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM302889 (1-(2-((2S,4R)-2-(6- chloropyridin-2- ylcarbamoyl)-...) Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Cl)n2)c2ccc(Nc3cncnc3)cc12 |r| Show InChI InChI=1S/C24H21ClFN9O3/c25-19-2-1-3-20(31-19)32-24(38)18-6-13(26)10-34(18)21(36)11-35-17-5-4-14(30-15-8-28-12-29-9-15)7-16(17)22(33-35)23(27)37/h1-5,7-9,12-13,18,30H,6,10-11H2,(H2,27,37)(H,31,32,38)/t13-,18+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. US Patent					Assay Description Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...				US Patent US10660876 (2020)
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM302889 (1-(2-((2S,4R)-2-(6- chloropyridin-2- ylcarbamoyl)-...) Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Cl)n2)c2ccc(Nc3cncnc3)cc12 |r| Show InChI InChI=1S/C24H21ClFN9O3/c25-19-2-1-3-20(31-19)32-24(38)18-6-13(26)10-34(18)21(36)11-35-17-5-4-14(30-15-8-28-12-29-9-15)7-16(17)22(33-35)23(27)37/h1-5,7-9,12-13,18,30H,6,10-11H2,(H2,27,37)(H,31,32,38)/t13-,18+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ACHILLION PHARMACEUTICALS, INC. US Patent					Assay Description Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...				US Patent US9598446 (2017) BindingDB Entry DOI: 10.7270/Q2ST7RWF
					More data for this Ligand-Target Pair