BDBM302893 1-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- ylcarbamoyl)-4- fluoropyrrolidin-1-yl)- 2-oxoethyl)-5-(5- cyanopyrimidin-2- ylamino)-1H- indazole-3- carboxamide::US10660876, Cmpd No. 13::US9598446, Compound 13

SMILES: NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccc(Nc3ncc(cn3)C#N)cc12

InChI Key: InChIKey=MUAYRPVDPJBKCK-DWXRJYCRSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 302893   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM302893 (1-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- y...) Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccc(Nc3ncc(cn3)C#N)cc12 |r| Show InChI InChI=1S/C32H24ClF2N9O3/c33-23-6-2-1-4-20(23)21-5-3-7-24(28(21)35)41-31(47)26-10-18(34)15-43(26)27(45)16-44-25-9-8-19(11-22(25)29(42-44)30(37)46)40-32-38-13-17(12-36)14-39-32/h1-9,11,13-14,18,26H,10,15-16H2,(H2,37,46)(H,41,47)(H,38,39,40)/t18-,26+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. US Patent					Assay Description Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...				US Patent US10660876 (2020)
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM302893 (1-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- y...) Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccc(Nc3ncc(cn3)C#N)cc12 |r| Show InChI InChI=1S/C32H24ClF2N9O3/c33-23-6-2-1-4-20(23)21-5-3-7-24(28(21)35)41-31(47)26-10-18(34)15-43(26)27(45)16-44-25-9-8-19(11-22(25)29(42-44)30(37)46)40-32-38-13-17(12-36)14-39-32/h1-9,11,13-14,18,26H,10,15-16H2,(H2,37,46)(H,41,47)(H,38,39,40)/t18-,26+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ACHILLION PHARMACEUTICALS, INC. US Patent					Assay Description Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...				US Patent US9598446 (2017) BindingDB Entry DOI: 10.7270/Q2ST7RWF
					More data for this Ligand-Target Pair