BDBM302900 1-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- ylcarbamoyl)-4- fluoropyrrolidin-1-yl)- 2-oxoethyl)-5-(2- (trifluoromethyl) pyrimidin- 5-ylamino)-1H- indazole-3- carboxamide::US10660876, Cmpd No. 14::US9598446, Compound 14

SMILES: NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccc(Nc3cnc(nc3)C(F)(F)F)cc12

InChI Key: InChIKey=XXYOBMWPJFTCBD-CPJLOUKISA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 302900   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM302900 (1-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- y...) Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccc(Nc3cnc(nc3)C(F)(F)F)cc12 |r| Show InChI InChI=1S/C32H24ClF5N8O3/c33-22-6-2-1-4-19(22)20-5-3-7-23(27(20)35)43-30(49)25-10-16(34)14-45(25)26(47)15-46-24-9-8-17(11-21(24)28(44-46)29(39)48)42-18-12-40-31(41-13-18)32(36,37)38/h1-9,11-13,16,25,42H,10,14-15H2,(H2,39,48)(H,43,49)/t16-,25+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. US Patent					Assay Description Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...				US Patent US10660876 (2020)
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM302900 (1-(2-((2S,4R)-2-(2'- chloro-2- fluorobiphenyl-3- y...) Show SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccc(Nc3cnc(nc3)C(F)(F)F)cc12 |r| Show InChI InChI=1S/C32H24ClF5N8O3/c33-22-6-2-1-4-19(22)20-5-3-7-23(27(20)35)43-30(49)25-10-16(34)14-45(25)26(47)15-46-24-9-8-17(11-21(24)28(44-46)29(39)48)42-18-12-40-31(41-13-18)32(36,37)38/h1-9,11-13,16,25,42H,10,14-15H2,(H2,39,48)(H,43,49)/t16-,25+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ACHILLION PHARMACEUTICALS, INC. US Patent					Assay Description Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...				US Patent US9598446 (2017) BindingDB Entry DOI: 10.7270/Q2ST7RWF
					More data for this Ligand-Target Pair