BDBM303009 (2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1H-indol-1- yl)acetyl)-N-(5- bromopyridin-3-yl)-4- fluoropyrrolidine-2- carboxamide::US10660876, Cmpd No. 21::US9598446, Compound 21
SMILES: CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cncc(Br)c2)c2ccc(Nc3cncnc3)cc12
InChI Key: InChIKey=KCCSOWPTTFVCBI-OSPHWJPCSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Complement factor D (Homo sapiens (Human)) | BDBM303009 ((2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Achillion Pharmaceuticals, Inc. US Patent | Assay Description Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce... | US Patent US10660876 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor D (Homo sapiens (Human)) | BDBM303009 ((2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ACHILLION PHARMACEUTICALS, INC. US Patent | Assay Description Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce... | US Patent US9598446 (2017) BindingDB Entry DOI: 10.7270/Q2ST7RWF | |||||||||||
More data for this Ligand-Target Pair |