BDBM303037 (2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1H-indol-1- yl)acetyl)-4-fluoro-N- (1-(1-methyl-1H- pyrazol-4- yl)piperidin-3- yl)pyrrolidine-2- carboxamide::US10660876, Cmpd No. 42::US9598446, Compound 42

SMILES: CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NC2CCCN(C2)c2cnn(C)c2)c2ccc(Nc3cncnc3)cc12

InChI Key: InChIKey=MWQHZUNYDRLVBN-YOBMCTMISA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 303037   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM303037 ((2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1...) Show SMILES CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NC2CCCN(C2)c2cnn(C)c2)c2ccc(Nc3cncnc3)cc12 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;$| Show InChI InChI=1S/C30H34FN9O3/c1-19(41)26-16-39(27-6-5-21(9-25(26)27)35-23-10-32-18-33-11-23)17-29(42)40-13-20(31)8-28(40)30(43)36-22-4-3-7-38(14-22)24-12-34-37(2)15-24/h5-6,9-12,15-16,18,20,22,28,35H,3-4,7-8,13-14,17H2,1-2H3,(H,36,43)/t20-,22?,28+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. US Patent					Assay Description Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...				US Patent US10660876 (2020)
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM303037 ((2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1...) Show SMILES CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NC2CCCN(C2)c2cnn(C)c2)c2ccc(Nc3cncnc3)cc12 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;$| Show InChI InChI=1S/C30H34FN9O3/c1-19(41)26-16-39(27-6-5-21(9-25(26)27)35-23-10-32-18-33-11-23)17-29(42)40-13-20(31)8-28(40)30(43)36-22-4-3-7-38(14-22)24-12-34-37(2)15-24/h5-6,9-12,15-16,18,20,22,28,35H,3-4,7-8,13-14,17H2,1-2H3,(H,36,43)/t20-,22?,28+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ACHILLION PHARMACEUTICALS, INC. US Patent					Assay Description Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...				US Patent US9598446 (2017) BindingDB Entry DOI: 10.7270/Q2ST7RWF
					More data for this Ligand-Target Pair