BDBM303053 (2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1H-indol-1- yl)acetyl)-N-(1-(2- chlorophenyl)-2- oxopiperidin-3-yl)-4- fluoropyrrolidine-2- carboxamide::US10660876, Cmpd No. 58::US9598446, Compound 58

SMILES: CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NC2CCCN(C2=O)c2ccccc2Cl)c2ccc(Nc3cncnc3)cc12

InChI Key: InChIKey=UBXVSJSUZAETKL-QHSCGPOWSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 303053   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM303053 ((2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1...) Show SMILES CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NC2CCCN(C2=O)c2ccccc2Cl)c2ccc(Nc3cncnc3)cc12 |r| Show InChI InChI=1S/C32H31ClFN7O4/c1-19(42)24-16-39(27-9-8-21(12-23(24)27)37-22-13-35-18-36-14-22)17-30(43)41-15-20(34)11-29(41)31(44)38-26-6-4-10-40(32(26)45)28-7-3-2-5-25(28)33/h2-3,5,7-9,12-14,16,18,20,26,29,37H,4,6,10-11,15,17H2,1H3,(H,38,44)/t20-,26?,29+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. US Patent					Assay Description Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...				US Patent US10660876 (2020)
					More data for this Ligand-Target Pair
Complement factor D (Homo sapiens (Human))	BDBM303053 ((2S,4R)-1-(2-(3- acetyl-5-(pyrimidin-5- ylamino)-1...) Show SMILES CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NC2CCCN(C2=O)c2ccccc2Cl)c2ccc(Nc3cncnc3)cc12 |r| Show InChI InChI=1S/C32H31ClFN7O4/c1-19(42)24-16-39(27-9-8-21(12-23(24)27)37-22-13-35-18-36-14-22)17-30(43)41-15-20(34)11-29(41)31(44)38-26-6-4-10-40(32(26)45)28-7-3-2-5-25(28)33/h2-3,5,7-9,12-14,16,18,20,26,29,37H,4,6,10-11,15,17H2,1H3,(H,38,44)/t20-,26?,29+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ACHILLION PHARMACEUTICALS, INC. US Patent					Assay Description Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...				US Patent US9598446 (2017) BindingDB Entry DOI: 10.7270/Q2ST7RWF
					More data for this Ligand-Target Pair