null
SMILES: Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C1OC(=O)NC1=O
InChI Key: InChIKey=GJHZRRYSYJHQQN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human)) | BDBM303127 (5-[6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description Levels of (2R)-2-hydroxyglutarate (2HG) were measured in medium of a cell line with overexpression of mutated isocitrate dehydrogenase (mIDH) protein... | US Patent US10137110 (2018) BindingDB Entry DOI: 10.7270/Q2J968F3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Homo sapiens (Human)) | BDBM303127 (5-[6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Pharma Aktiengesellschaft US Patent | Assay Description mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by... | US Patent US10137110 (2018) BindingDB Entry DOI: 10.7270/Q2J968F3 | |||||||||||
More data for this Ligand-Target Pair |