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SMILES: CN1CCC(COc2cncc(c2)-n2cc(cn2)-c2cc(C(=O)NC3CC3)c(F)cc2C)C1

InChI Key: InChIKey=HSADOPRBLMFIQN-UHFFFAOYSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 303444   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM303444
PNG
(US10138222, Example 172)
Show SMILES CN1CCC(COc2cncc(c2)-n2cc(cn2)-c2cc(C(=O)NC3CC3)c(F)cc2C)C1
Show InChI InChI=1S/C25H28FN5O2/c1-16-7-24(26)23(25(32)29-19-3-4-19)9-22(16)18-10-28-31(14-18)20-8-21(12-27-11-20)33-15-17-5-6-30(2)13-17/h7-12,14,17,19H,3-6,13,15H2,1-2H3,(H,29,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...

US Patent US10138222 (2018)


BindingDB Entry DOI: 10.7270/Q2RV0QS2
More data for this
Ligand-Target Pair