BDBM303905 N-Cyclopropyl-2-fluoro-4-methyl-5-{1-[6-(1-oxetan-3-yl-piperidin-4-yl)-imidazo[1,2-a]pyridin-3-yl]-1H-pyrazol-4-yl}-benzamide::US10138241, Example 92
SMILES: Cc1cc(F)c(cc1-c1cnn(c1)-c1cnc2ccc(cn12)C1CCN(CC1)C1COC1)C(=O)NC1CC1
InChI Key: InChIKey=VFXVWOBVXVGDSU-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase RIPK2 (Homo sapiens (Human)) | BDBM303905 (N-Cyclopropyl-2-fluoro-4-methyl-5-{1-[6-(1-oxetan-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15... | US Patent US10138241 (2018) BindingDB Entry DOI: 10.7270/Q2VM4FBZ | |||||||||||
More data for this Ligand-Target Pair |