BDBM304037 5,8-Dimethyl-2-[2-(1,3-thiazol-2-yl)-1H-benz-imidazol-5-yl][1,2,4]triazolo[1,5-a]pyrazine::US10138245, Example 8

SMILES: Cc1cnc(C)c2nc(nn12)-c1ccc2[nH]c(nc2c1)-c1nccs1

InChI Key: InChIKey=ANKFMXLEHZORKJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 304037   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM304037 (5,8-Dimethyl-2-[2-(1,3-thiazol-2-yl)-1H-benz-imida...) Show SMILES Cc1cnc(C)c2nc(nn12)-c1ccc2[nH]c(nc2c1)-c1nccs1 Show InChI InChI=1S/C17H13N7S/c1-9-8-19-10(2)16-22-14(23-24(9)16)11-3-4-12-13(7-11)21-15(20-12)17-18-5-6-25-17/h3-8H,1-2H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
CELON PHARMA S.A. US Patent					Assay Description Recombinant human phosphodiesterase 10A (PDE10A) purified to homogeneity from Sf9 cells overexpressing PDE10A gene (GenBank/EMBL accession number: NM...				US Patent US10138245 (2018) BindingDB Entry DOI: 10.7270/Q2M32XTX
					More data for this Ligand-Target Pair