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BDBM30429 pyridazinone derivative, 8h

SMILES: CNC(=O)COc1ccc2N=C(NS(=O)(=O)c2c1)c1c(O)c(nn(CCC(C)C)c1=O)-c1cccs1

InChI Key: InChIKey=ZHSXQHKIZOENIY-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 30429   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Non-structural protein 5B (NS5B)


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM30429
PNG
(pyridazinone derivative, 8h)
Show SMILES CNC(=O)COc1ccc2N=C(NS(=O)(=O)c2c1)c1c(O)c(nn(CCC(C)C)c1=O)-c1cccs1 |c:10|
Show InChI InChI=1S/C23H25N5O6S2/c1-13(2)8-9-28-23(31)19(21(30)20(26-28)16-5-4-10-35-16)22-25-15-7-6-14(34-12-18(29)24-3)11-17(15)36(32,33)27-22/h4-7,10-11,13,30H,8-9,12H2,1-3H3,(H,24,29)(H,25,27)
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Article
PubMed
n/an/a 92n/a 710n/an/a7.528



Anadys Pharmaceuticals



Assay Description
Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...

Bioorg Med Chem Lett 18: 1413-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.007
BindingDB Entry DOI: 10.7270/Q22N50MR
More data for this
Ligand-Target Pair