BDBM30430 pyridazinone derivative, 8i
SMILES: CC(C)CCn1nc(-c2cccs2)c(O)c(C2=Nc3ccc(OCC(=O)NO)cc3S(=O)(=O)N2)c1=O
InChI Key: InChIKey=QQQNUPKTFJRVEI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Non-structural protein 5B (NS5B) (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30430 (pyridazinone derivative, 8i) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | 1.10E+3 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 1413-8 (2008) Article DOI: 10.1016/j.bmcl.2008.01.007 BindingDB Entry DOI: 10.7270/Q22N50MR | |||||||||||
More data for this Ligand-Target Pair |