BDBM304390 US10144715, Compound 9-5::methyl 2-(2-(tert-butyl)-4-(4-fluoro-3-(methylsulfonyl)phenyl)piperazin-1-yl)-4-(trifluoromethyl)pyrimidine-5-carboxylate

SMILES: COC(=O)c1cnc(nc1C(F)(F)F)N1CCN(CC1C(C)(C)C)c1ccc(F)c(c1)S(C)(=O)=O

InChI Key: InChIKey=CRRQUBDXEDTMJH-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304390   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM304390 (US10144715, Compound 9-5 | methyl 2-(2-(tert-butyl...) Show SMILES COC(=O)c1cnc(nc1C(F)(F)F)N1CCN(CC1C(C)(C)C)c1ccc(F)c(c1)S(C)(=O)=O Show InChI InChI=1S/C22H26F4N4O4S/c1-21(2,3)17-12-29(13-6-7-15(23)16(10-13)35(5,32)33)8-9-30(17)20-27-11-14(19(31)34-4)18(28-20)22(24,25)26/h6-7,10-11,17H,8-9,12H2,1-5H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc. US Patent					Assay Description Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...				US Patent US10144715 (2018) BindingDB Entry DOI: 10.7270/Q2PV6NFD
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM304390 (US10144715, Compound 9-5 | methyl 2-(2-(tert-butyl...) Show SMILES COC(=O)c1cnc(nc1C(F)(F)F)N1CCN(CC1C(C)(C)C)c1ccc(F)c(c1)S(C)(=O)=O Show InChI InChI=1S/C22H26F4N4O4S/c1-21(2,3)17-12-29(13-6-7-15(23)16(10-13)35(5,32)33)8-9-30(17)20-27-11-14(19(31)34-4)18(28-20)22(24,25)26/h6-7,10-11,17H,8-9,12H2,1-5H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc. US Patent					Assay Description Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...				US Patent US10144715 (2018) BindingDB Entry DOI: 10.7270/Q2PV6NFD
					More data for this Ligand-Target Pair