BDBM304425 (R)-2-(4-(4-(5-(hydroxymethyl)-4-(trifluoromethyl)pyrimidin-2-yl)-3-isopropylpiperazin-1-yl)-2-(methylsulfonyl)phenyl)thiazole-4-carbonitrile::US10144715, Compound 11-12

SMILES: CC(C)[C@@H]1CN(CCN1c1ncc(CO)c(n1)C(F)(F)F)c1ccc(-c2nc(cs2)C#N)c(c1)S(C)(=O)=O

InChI Key: InChIKey=MQKQOJAXHYOTRU-IBGZPJMESA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304425   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM304425 ((R)-2-(4-(4-(5-(hydroxymethyl)-4-(trifluoromethyl)...) Show SMILES CC(C)[C@@H]1CN(CCN1c1ncc(CO)c(n1)C(F)(F)F)c1ccc(-c2nc(cs2)C#N)c(c1)S(C)(=O)=O |r| Show InChI InChI=1S/C24H25F3N6O3S2/c1-14(2)19-11-32(6-7-33(19)23-29-10-15(12-34)21(31-23)24(25,26)27)17-4-5-18(20(8-17)38(3,35)36)22-30-16(9-28)13-37-22/h4-5,8,10,13-14,19,34H,6-7,11-12H2,1-3H3/t19-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc. US Patent					Assay Description Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...				US Patent US10144715 (2018) BindingDB Entry DOI: 10.7270/Q2PV6NFD
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM304425 ((R)-2-(4-(4-(5-(hydroxymethyl)-4-(trifluoromethyl)...) Show SMILES CC(C)[C@@H]1CN(CCN1c1ncc(CO)c(n1)C(F)(F)F)c1ccc(-c2nc(cs2)C#N)c(c1)S(C)(=O)=O |r| Show InChI InChI=1S/C24H25F3N6O3S2/c1-14(2)19-11-32(6-7-33(19)23-29-10-15(12-34)21(31-23)24(25,26)27)17-4-5-18(20(8-17)38(3,35)36)22-30-16(9-28)13-37-22/h4-5,8,10,13-14,19,34H,6-7,11-12H2,1-3H3/t19-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	194	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc. US Patent					Assay Description Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...				US Patent US10144715 (2018) BindingDB Entry DOI: 10.7270/Q2PV6NFD
					More data for this Ligand-Target Pair