BDBM30453 hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 4d
SMILES: CN(c1ccc2N=C(NS(=O)(=O)c2c1)C1C(=O)C2CCCN2N(CCC(C)(C)C)C1=O)S(C)(=O)=O
InChI Key: InChIKey=RCUXQVRJVGFLKQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Non-structural protein 5B (NS5B) (Hepatitis C virus genotype 1b (isolate BK) (HCV)) | BDBM30453 (hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 4d) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 160 | n/a | 3.60E+3 | n/a | n/a | 7.5 | 28 |
Anadys Pharmaceuticals | Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v... | Bioorg Med Chem Lett 18: 5002-5 (2008) Article DOI: 10.1016/j.bmcl.2008.08.017 BindingDB Entry DOI: 10.7270/Q2XW4H5X | |||||||||||
More data for this Ligand-Target Pair |