BDBM3046 3-{7,19-dimethoxy-23-methyl-12,14-dioxo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-3-yl}propanenitrile::Indolocarbazole deriv. 3n
SMILES: COc1ccc2n(C)c3c(c4C(=O)NC(=O)c4c4c5cc(OC)ccc5n(CCC#N)c34)c2c1
InChI Key: InChIKey=KDSNLSHGOJHLPI-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Myosin light chain kinase, smooth muscle (Gallus gallus (chicken)) | BDBM3046 (3-{7,19-dimethoxy-23-methyl-12,14-dioxo-3,13,23-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article | n/a | n/a | 180 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Tumor Biology Center | Assay Description The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain. | Bioorg Med Chem Lett 5: 55-60 (1995) Article DOI: 10.1016/0960-894X(94)00458-R BindingDB Entry DOI: 10.7270/Q2CF9N8C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myosin light chain kinase, smooth muscle (Homo sapiens (Human)) | BDBM3046 (3-{7,19-dimethoxy-23-methyl-12,14-dioxo-3,13,23-tr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Tumor Biology Center | Assay Description Tested for inhibition of Myosin light chain kinase from chicken gizzard | Bioorg Med Chem Lett 5: 55-60 (1995) Article DOI: 10.1016/0960-894X(94)00458-R BindingDB Entry DOI: 10.7270/Q2CF9N8C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Kinase C (Rattus norvegicus (rat)) | BDBM3046 (3-{7,19-dimethoxy-23-methyl-12,14-dioxo-3,13,23-tr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Tumor Biology Center | Assay Description The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi... | Bioorg Med Chem Lett 5: 55-60 (1995) Article DOI: 10.1016/0960-894X(94)00458-R BindingDB Entry DOI: 10.7270/Q2CF9N8C | |||||||||||
More data for this Ligand-Target Pair |