BDBM30478 1,1-dioxoisothiazole analog., 22

SMILES: CCOc1cccc2C(NS(=O)(=O)c12)=C1C(=O)[C@H](C(C)C)N(CCC(C)(C)C)C1=O

InChI Key: InChIKey=JGGNBBGZFQYFBZ-SFHVURJKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 30478   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-structural protein 5B (NS5B) (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM30478 (1,1-dioxoisothiazole analog., 22) Show SMILES CCOc1cccc2C(NS(=O)(=O)c12)=C1C(=O)[C@H](C(C)C)N(CCC(C)(C)C)C1=O |r,w:14.16| Show InChI InChI=1S/C22H30N2O5S/c1-7-29-15-10-8-9-14-17(23-30(27,28)20(14)15)16-19(25)18(13(2)3)24(21(16)26)12-11-22(4,5)6/h8-10,13,18,23H,7,11-12H2,1-6H3/t18-/m0/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	7.5	28
Anadys Pharmaceuticals					Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...				Bioorg Med Chem Lett 18: 4181-5 (2008) Article DOI: 10.1016/j.bmcl.2008.05.083 BindingDB Entry DOI: 10.7270/Q2PC30Q5
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