BDBM30479 1,1-dioxoisothiazole analog., 23

SMILES: CCOc1cccc2C(NS(=O)(=O)c12)=C1C(=O)[C@@H](N(CCC(C)(C)C)C1=O)C(C)(C)C

InChI Key: InChIKey=LBONSROQGQHAKQ-HXUWFJFHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 30479   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-structural protein 5B (NS5B) (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM30479 (1,1-dioxoisothiazole analog., 23) Show SMILES CCOc1cccc2C(NS(=O)(=O)c12)=C1C(=O)[C@@H](N(CCC(C)(C)C)C1=O)C(C)(C)C |r,w:14.16| Show InChI InChI=1S/C23H32N2O5S/c1-8-30-15-11-9-10-14-17(24-31(28,29)19(14)15)16-18(26)20(23(5,6)7)25(21(16)27)13-12-22(2,3)4/h9-11,20,24H,8,12-13H2,1-7H3/t20-/m1/s1	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	7.5	28
Anadys Pharmaceuticals					Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...				Bioorg Med Chem Lett 18: 4181-5 (2008) Article DOI: 10.1016/j.bmcl.2008.05.083 BindingDB Entry DOI: 10.7270/Q2PC30Q5
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