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SMILES: CC(C)(C)[C@@H]1N(Cc2ccc(F)c(Cl)c2)C(=O)C(C1=O)=C1NS(=O)(=O)c2c1cccc2OCc1ncon1

InChI Key: InChIKey=CYJMQPWMAMBWDX-HSZRJFAPSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 30489   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Genome polyprotein


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM30489
PNG
(1,1-dioxoisothiazole analog., 33)
Show SMILES CC(C)(C)[C@@H]1N(Cc2ccc(F)c(Cl)c2)C(=O)C(C1=O)=C1NS(=O)(=O)c2c1cccc2OCc1ncon1 |r,w:17.18|
Show InChI InChI=1S/C25H22ClFN4O6S/c1-25(2,3)23-21(32)19(24(33)31(23)10-13-7-8-16(27)15(26)9-13)20-14-5-4-6-17(22(14)38(34,35)30-20)36-11-18-28-12-37-29-18/h4-9,12,23,30H,10-11H2,1-3H3/t23-/m1/s1
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 180n/a 1.80E+3n/an/a7.528



Anadys Pharmaceuticals



Assay Description
Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...

Bioorg Med Chem Lett 18: 4181-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.083
BindingDB Entry DOI: 10.7270/Q2PC30Q5
More data for this
Ligand-Target Pair