BDBM30506 5,6-Dihydro-1H-pyridin-2-one, 4f

SMILES: CS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)C1C(=O)C2CCCCCC2N(Cc2ccc(F)cc2)C1=O

InChI Key: InChIKey=GXUPEENOMHCBCQ-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 30506   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HCV NS3-NS4A Serine Proteinase (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM30506 (5,6-Dihydro-1H-pyridin-2-one, 4f) Show SMILES CS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)C1C(=O)C2CCCCCC2N(Cc2ccc(F)cc2)C1=O |c:9| Show InChI InChI=1S/C25H27FN4O6S2/c1-37(33,34)28-17-11-12-19-21(13-17)38(35,36)29-24(27-19)22-23(31)18-5-3-2-4-6-20(18)30(25(22)32)14-15-7-9-16(26)10-8-15/h7-13,18,20,22,28H,2-6,14H2,1H3,(H,27,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Anadys Pharmaceuticals					Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...				Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0
					More data for this Ligand-Target Pair
Non-structural protein 5B (NS5B) (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM30506 (5,6-Dihydro-1H-pyridin-2-one, 4f) Show SMILES CS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)C1C(=O)C2CCCCCC2N(Cc2ccc(F)cc2)C1=O |c:9| Show InChI InChI=1S/C25H27FN4O6S2/c1-37(33,34)28-17-11-12-19-21(13-17)38(35,36)29-24(27-19)22-23(31)18-5-3-2-4-6-20(18)30(25(22)32)14-15-7-9-16(26)10-8-15/h7-13,18,20,22,28H,2-6,14H2,1H3,(H,27,29)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	57	n/a	74	n/a	n/a	7.5	28
Anadys Pharmaceuticals					Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...				Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0
					More data for this Ligand-Target Pair