null

SMILES: CS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)C1C(=O)C2CCCC2N(Cc2ccc(F)cn2)C1=O

InChI Key: InChIKey=ADTUHMOANHJXBG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 30525   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Genome polyprotein (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM30525 (5,6-Dihydro-1H-pyridin-2-one, 4y) Show SMILES CS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)C1C(=O)C2CCCC2N(Cc2ccc(F)cn2)C1=O |c:9| Show InChI InChI=1S/C22H22FN5O6S2/c1-35(31,32)26-13-7-8-16-18(9-13)36(33,34)27-21(25-16)19-20(29)15-3-2-4-17(15)28(22(19)30)11-14-6-5-12(23)10-24-14/h5-10,15,17,19,26H,2-4,11H2,1H3,(H,25,27)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Anadys Pharmaceuticals					Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...				Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0
					More data for this Ligand-Target Pair
Genome polyprotein (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM30525 (5,6-Dihydro-1H-pyridin-2-one, 4y) Show SMILES CS(=O)(=O)Nc1ccc2N=C(NS(=O)(=O)c2c1)C1C(=O)C2CCCC2N(Cc2ccc(F)cn2)C1=O |c:9| Show InChI InChI=1S/C22H22FN5O6S2/c1-35(31,32)26-13-7-8-16-18(9-13)36(33,34)27-21(25-16)19-20(29)15-3-2-4-17(15)28(22(19)30)11-14-6-5-12(23)10-24-14/h5-10,15,17,19,26H,2-4,11H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	3.10E+3	n/a	n/a	7.5	28
Anadys Pharmaceuticals					Assay Description Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...				Bioorg Med Chem Lett 19: 451-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.048 BindingDB Entry DOI: 10.7270/Q2JM27Z0
					More data for this Ligand-Target Pair