BDBM306371 (+-)-N-[(6-amino-2,4- dimethylpyridin-3-yl)- methyl]-12-[(1H- pyrazol-1-yl)(2H2)methyl]-15- oxatetracyclo[6.6.1.02,7.09,14] pentadeca-2,4,6,9,11,13- hexaene-4-carboxamide::US10144746, Compound 13

SMILES: Cc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c4cc(CN5CCC=N5)ccc34)c2c1

InChI Key: InChIKey=ATZLFBTZFGGWEB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306371   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306371 ((+-)-N-[(6-amino-2,4- dimethylpyridin-3-yl)- methy...) Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c4cc(CN5CCC=N5)ccc34)c2c1 |c:28| Show InChI InChI=1S/C27H27N5O2/c1-15-10-24(28)31-16(2)23(15)13-29-27(33)18-5-7-20-22(12-18)26-21-11-17(14-32-9-3-8-30-32)4-6-19(21)25(20)34-26/h4-8,10-12,25-26H,3,9,13-14H2,1-2H3,(H2,28,31)(H,29,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.79	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
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