BDBM306494 (+-)-N-[(6-amino-4-ethyl-2- methylpyridin-3-yl)methyl]-12- (2-cyano-4-methylphenyl)-15- oxatetracyclo[6.6.1.02,7.09,14] pentadeca-2,4,6,9,11,13- hexaene-4-carboxamide::US10144746, Compound 136

SMILES: CCc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c2c1)c1cc(ccc31)-c1ccc(C)cc1C#N

InChI Key: InChIKey=WWQQLOVTRXFOTE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306494   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306494 ((+-)-N-[(6-amino-4-ethyl-2- methylpyridin-3-yl)met...) Show SMILES CCc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c2c1)c1cc(ccc31)-c1ccc(C)cc1C#N Show InChI InChI=1S/C32H28N4O2/c1-4-19-14-29(34)36-18(3)28(19)16-35-32(37)21-7-10-25-27(13-21)31-26-12-20(6-9-24(26)30(25)38-31)23-8-5-17(2)11-22(23)15-33/h5-14,30-31H,4,16H2,1-3H3,(H2,34,36)(H,35,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.98	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
					More data for this Ligand-Target Pair