BDBM306574 (1S,8R)-N-[(4- carbamimidoylphenyl)methyl]- 12-(5-chlorothiophen-2-yl)-15- oxatetracyclo- [6.6.1.02,7.09,14]pentadeca- 2,4,6,9,11,13-hexaene-4- carboxamide::US10144746, Compound 217

SMILES: NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(Cl)s2)cc1

InChI Key: InChIKey=MHQDMBCAMZUIKY-LOSJGSFVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306574   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306574 ((1S,8R)-N-[(4- carbamimidoylphenyl)methyl]- 12-(5-...) Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(Cl)s2)cc1 |r| Show InChI InChI=1S/C27H20ClN3O2S/c28-23-10-9-22(34-23)16-5-7-18-20(11-16)25-21-12-17(6-8-19(21)24(18)33-25)27(32)31-13-14-1-3-15(4-2-14)26(29)30/h1-12,24-25H,13H2,(H3,29,30)(H,31,32)/t24-,25+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
					More data for this Ligand-Target Pair