BDBM306625 (1R,8S)-N-[(6-carbamimidoyl- pyridin-3-yl)-methyl]-12-(2,4- difluorophenyl)-15-oxatetracyclo [6.6.1.02,7.09,14]pentadeca- 2,4,6,9,11,13-hexaene-4- carboxamide::US10144746, Compound 268

SMILES: NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2F)cn1

InChI Key: InChIKey=CQLIKLLIHOWWPO-IZZNHLLZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306625   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306625 ((1R,8S)-N-[(6-carbamimidoyl- pyridin-3-yl)-methyl]...) Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2F)cn1 |r| Show InChI InChI=1S/C28H20F2N4O2/c29-17-4-7-18(23(30)11-17)15-2-5-19-21(9-15)26-22-10-16(3-6-20(22)25(19)36-26)28(35)34-13-14-1-8-24(27(31)32)33-12-14/h1-12,25-26H,13H2,(H3,31,32)(H,34,35)/t25-,26+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.01	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
					More data for this Ligand-Target Pair