BDBM306642 (1R,8S)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)methyl]- 12-(prop-1-en-2-yl)-15- oxatetracyclo[6.6.1.02,7.09,14] pentadeca-2,4,6,9,11,l3- hexaene-4-carboxamide::US10144746, Compound 285

SMILES: CC(=C)c1ccc2[C@@H]3O[C@H](c2c1)c1cc(ccc31)C(=O)NCc1c(F)cc(cc1F)C(N)=N

InChI Key: InChIKey=MKRQBUJZVKUPFP-BJKOFHAPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306642   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306642 ((1R,8S)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)m...) Show SMILES CC(=C)c1ccc2[C@@H]3O[C@H](c2c1)c1cc(ccc31)C(=O)NCc1c(F)cc(cc1F)C(N)=N |r| Show InChI InChI=1S/C26H21F2N3O2/c1-12(2)13-3-5-16-18(7-13)24-19-8-14(4-6-17(19)23(16)33-24)26(32)31-11-20-21(27)9-15(25(29)30)10-22(20)28/h3-10,23-24H,1,11H2,2H3,(H3,29,30)(H,31,32)/t23-,24+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
					More data for this Ligand-Target Pair