BDBM306652 (1R,8S)-N-((4-carbamimidoyl- 2,6-difluorophenyl)methyl]- 12-(3,3,3-trifluoropropyl)-15- oxatetracyclo[6.6.1.02,7.09,14] pentadeca-2,4,6,9,11,13- hexaene-4-carboxamide::US10144746, Compound 296

SMILES: NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(CCC(F)(F)F)ccc45)c3c2)c(F)c1

InChI Key: InChIKey=WOSFAHWCDJJYHI-XZOQPEGZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306652   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306652 ((1R,8S)-N-((4-carbamimidoyl- 2,6-difluorophenyl)me...) Show SMILES NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(CCC(F)(F)F)ccc45)c3c2)c(F)c1 |r| Show InChI InChI=1S/C26H20F5N3O2/c27-20-9-14(24(32)33)10-21(28)19(20)11-34-25(35)13-2-4-16-18(8-13)23-17-7-12(5-6-26(29,30)31)1-3-15(17)22(16)36-23/h1-4,7-10,22-23H,5-6,11H2,(H3,32,33)(H,34,35)/t22-,23+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
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