BDBM306658 (1R,8S)-N-[(4-carbamimidoyl-2- fluorophenyl)-methyl]-12- cyclopropyl-15-oxatetracyclo- [6.6.1.02,7.09,14]pentadeca- 2,4,6,9,11,13-hexaene-4- carboxamide::US10144746, Compound 302

SMILES: NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(ccc45)C4CC4)c3c2)c(F)c1

InChI Key: InChIKey=HLQBNDDUQPDVLL-BJKOFHAPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306658   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306658 ((1R,8S)-N-[(4-carbamimidoyl-2- fluorophenyl)-methy...) Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(ccc45)C4CC4)c3c2)c(F)c1 |r| Show InChI InChI=1S/C26H22FN3O2/c27-22-11-15(25(28)29)3-4-17(22)12-30-26(31)16-6-8-19-21(10-16)24-20-9-14(13-1-2-13)5-7-18(20)23(19)32-24/h3-11,13,23-24H,1-2,12H2,(H3,28,29)(H,30,31)/t23-,24+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
					More data for this Ligand-Target Pair