BDBM306685 (1R,8S)-N-[(4-carbamimidoyl- 2-fluorophenyl)-methyl]-12- (4-fluorophenyl)-15- oxatetracyclo[6.6.1.02,7.09,14] pentadeca-2,4,6,9,11,13-hexaene- 4-carboxamide::US10144746, Compound 329

SMILES: NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2)c(F)c1

InChI Key: InChIKey=OSFMJFGBSHHRAI-RRPNLBNLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306685   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306685 ((1R,8S)-N-[(4-carbamimidoyl- 2-fluorophenyl)-methy...) Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2)c(F)c1 |r| Show InChI InChI=1S/C29H21F2N3O2/c30-20-7-3-15(4-8-20)16-5-9-21-23(11-16)27-24-12-18(6-10-22(24)26(21)36-27)29(35)34-14-19-2-1-17(28(32)33)13-25(19)31/h1-13,26-27H,14H2,(H3,32,33)(H,34,35)/t26-,27+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
					More data for this Ligand-Target Pair