BDBM306703 (1S,8R)-N-[(4- carbamimidoylphenyl) methyl]-11,12-diethyl- 15-oxatetracyclo [6.6.1.02,7.09,14] pentadeca- 2,4,6,9(14),10,12- hexaene-4-carboxamide::US10144746, Compound 392

SMILES: CCc1cc2[C@@H]3O[C@H](c2cc1CC)c1cc(ccc31)C(=O)NCc1ccc(cc1)C(N)=N

InChI Key: InChIKey=XROGSPJLCQLFQP-RPBOFIJWSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306703   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306703 ((1S,8R)-N-[(4- carbamimidoylphenyl) methyl]-11,12-...) Show SMILES CCc1cc2[C@@H]3O[C@H](c2cc1CC)c1cc(ccc31)C(=O)NCc1ccc(cc1)C(N)=N |r| Show InChI InChI=1S/C27H27N3O2/c1-3-16-11-22-23(12-17(16)4-2)25-21-13-19(9-10-20(21)24(22)32-25)27(31)30-14-15-5-7-18(8-6-15)26(28)29/h5-13,24-25H,3-4,14H2,1-2H3,(H3,28,29)(H,30,31)/t24-,25+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
					More data for this Ligand-Target Pair