BDBM306704 (+-)-N-[(4- carbamimidoylphenyl) methyl]-6-fluoro-12-(4- fluorophenyl)-10-methyl-15- oxatetracyclo[6.6.1.02,7.09,14] pentadeca- 2(7),3,5,9(14),10,12- hexaene-4-carboxamide::US10144746, Compound 396

SMILES: Cc1cc(cc2C3OC(c12)c1c3cc(cc1F)C(=O)NCc1ccc(cc1)C(N)=N)-c1ccc(F)cc1

InChI Key: InChIKey=SJUIOQOVYSVNHN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306704   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306704 ((+-)-N-[(4- carbamimidoylphenyl) methyl]-6-fluoro-...) Show SMILES Cc1cc(cc2C3OC(c12)c1c3cc(cc1F)C(=O)NCc1ccc(cc1)C(N)=N)-c1ccc(F)cc1 Show InChI InChI=1S/C30H23F2N3O2/c1-15-10-19(17-6-8-21(31)9-7-17)11-22-25(15)28-26-23(27(22)37-28)12-20(13-24(26)32)30(36)35-14-16-2-4-18(5-3-16)29(33)34/h2-13,27-28H,14H2,1H3,(H3,33,34)(H,35,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.01	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
					More data for this Ligand-Target Pair