BDBM306708 (1S,8R)-N-[(4-carbamimidoyl- phenyl)methyl]-11,12- dicyclopropyl-15- oxatetracyclo [6.6.1.02,7.09,14]pentadeca- 2,4,6,9,11,13-hexaene-4- carboxamide::US10144746, Compound 400

SMILES: NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(C3CC3)c(cc42)C2CC2)cc1

InChI Key: InChIKey=PATKGAJHNVAGIU-SXOMAYOGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306708   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM306708 ((1S,8R)-N-[(4-carbamimidoyl- phenyl)methyl]-11,12-...) Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(C3CC3)c(cc42)C2CC2)cc1 |r| Show InChI InChI=1S/C29H27N3O2/c30-28(31)18-3-1-15(2-4-18)14-32-29(33)19-9-10-20-23(11-19)27-25-13-22(17-7-8-17)21(16-5-6-16)12-24(25)26(20)34-27/h1-4,9-13,16-17,26-27H,5-8,14H2,(H3,30,31)(H,32,33)/t26-,27+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Global Blood Therapeutics, Inc. US Patent					Assay Description The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...				US Patent US10144746 (2018) BindingDB Entry DOI: 10.7270/Q2J38VNH
					More data for this Ligand-Target Pair