BDBM307548 N-(bicyclo[1.1.1]pentan-1-yl)-5-(6-ethoxy-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxynicotinamide::US10150747, Example 15

SMILES: CCOc1cc2oc(c(C(=O)NC)c2cc1-c1cnc(OC)c(c1)C(=O)NC12CC11CC1C2)-c1ccc(F)cc1

InChI Key: InChIKey=GOAWCMFBIKMWKZ-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307548   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RNA polymerase (NS5B) (Hepatitis C virus (HCV))	BDBM307548 (N-(bicyclo[1.1.1]pentan-1-yl)-5-(6-ethoxy-2-(4-flu...) Show SMILES CCOc1cc2oc(c(C(=O)NC)c2cc1-c1cnc(OC)c(c1)C(=O)NC12CC11CC1C2)-c1ccc(F)cc1 Show InChI InChI=1S/C31H28FN3O5/c1-4-39-23-11-24-21(25(28(37)33-2)26(40-24)16-5-7-19(32)8-6-16)10-20(23)17-9-22(29(38-3)34-14-17)27(36)35-31-13-18-12-30(18,31)15-31/h5-11,14,18H,4,12-13,15H2,1-3H3,(H,33,37)(H,35,36)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.03	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...				US Patent US10150747 (2018) BindingDB Entry DOI: 10.7270/Q2H70HWJ
					More data for this Ligand-Target Pair
RNA polymerase (NS5B) (Hepatitis C virus (HCV))	BDBM307548 (N-(bicyclo[1.1.1]pentan-1-yl)-5-(6-ethoxy-2-(4-flu...) Show SMILES CCOc1cc2oc(c(C(=O)NC)c2cc1-c1cnc(OC)c(c1)C(=O)NC12CC11CC1C2)-c1ccc(F)cc1 Show InChI InChI=1S/C31H28FN3O5/c1-4-39-23-11-24-21(25(28(37)33-2)26(40-24)16-5-7-19(32)8-6-16)10-20(23)17-9-22(29(38-3)34-14-17)27(36)35-31-13-18-12-30(18,31)15-31/h5-11,14,18H,4,12-13,15H2,1-3H3,(H,33,37)(H,35,36)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.48	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...				US Patent US10150747 (2018) BindingDB Entry DOI: 10.7270/Q2H70HWJ
					More data for this Ligand-Target Pair