BDBM307609 2-(6-(4-Cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)isoindolin-1-one ::US10150755, Compound 1

SMILES: O=C1N(Cc2ccccc12)c1cccc(n1)-c1nncn1C1CC1

InChI Key: InChIKey=OBYPIQGEFWHGBZ-UHFFFAOYSA-N

Data: 2 KI  1 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 307609   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM307609 (2-(6-(4-Cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...) Show SMILES O=C1N(Cc2ccccc12)c1cccc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C18H15N5O/c24-18-14-5-2-1-4-12(14)10-22(18)16-7-3-6-15(20-16)17-21-19-11-23(17)13-8-9-13/h1-7,11,13H,8-10H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SEAL ROCK THERAPEUTICS, INC. US Patent					Assay Description The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...				US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q2125VQ8
					More data for this Ligand-Target Pair
Myosin light chain kinase, smooth muscle (Homo sapiens (Human))	BDBM307609 (2-(6-(4-Cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...) Show SMILES O=C1N(Cc2ccccc12)c1cccc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C18H15N5O/c24-18-14-5-2-1-4-12(14)10-22(18)16-7-3-6-15(20-16)17-21-19-11-23(17)13-8-9-13/h1-7,11,13H,8-10H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SEAL ROCK THERAPEUTICS, INC. US Patent					Assay Description MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...				US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q2125VQ8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM307609 (2-(6-(4-Cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...) Show SMILES O=C1N(Cc2ccccc12)c1cccc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C18H15N5O/c24-18-14-5-2-1-4-12(14)10-22(18)16-7-3-6-15(20-16)17-21-19-11-23(17)13-8-9-13/h1-7,11,13H,8-10H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<200	n/a	n/a	n/a	n/a	n/a	n/a
SEAL ROCK THERAPEUTICS, INC. US Patent					Assay Description The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...				US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q27P91GS
					More data for this Ligand-Target Pair
Myosin light chain kinase, smooth muscle (Homo sapiens (Human))	BDBM307609 (2-(6-(4-Cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...) Show SMILES O=C1N(Cc2ccccc12)c1cccc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C18H15N5O/c24-18-14-5-2-1-4-12(14)10-22(18)16-7-3-6-15(20-16)17-21-19-11-23(17)13-8-9-13/h1-7,11,13H,8-10H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a
SEAL ROCK THERAPEUTICS, INC. US Patent					Assay Description MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...				US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q27P91GS
					More data for this Ligand-Target Pair