null

SMILES: CC(=O)N1CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1

InChI Key: InChIKey=SCQHVRVWJHVDET-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 307624   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM307624 (5-(4- acetylpiperazine-1- carbonyl)-2-(6-(4- cyclo...) Show SMILES CC(=O)N1CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C25H25N7O3/c1-16(33)29-9-11-30(12-10-29)24(34)17-5-8-20-18(13-17)14-31(25(20)35)22-4-2-3-21(27-22)23-28-26-15-32(23)19-6-7-19/h2-5,8,13,15,19H,6-7,9-12,14H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SEAL ROCK THERAPEUTICS, INC. US Patent					Assay Description The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...				US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q2125VQ8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM307624 (5-(4- acetylpiperazine-1- carbonyl)-2-(6-(4- cyclo...) Show SMILES CC(=O)N1CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C25H25N7O3/c1-16(33)29-9-11-30(12-10-29)24(34)17-5-8-20-18(13-17)14-31(25(20)35)22-4-2-3-21(27-22)23-28-26-15-32(23)19-6-7-19/h2-5,8,13,15,19H,6-7,9-12,14H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<200	n/a	n/a	n/a	n/a	n/a	n/a
SEAL ROCK THERAPEUTICS, INC. US Patent					Assay Description The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...				US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q27P91GS
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM307624 (5-(4- acetylpiperazine-1- carbonyl)-2-(6-(4- cyclo...) Show SMILES CC(=O)N1CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C25H25N7O3/c1-16(33)29-9-11-30(12-10-29)24(34)17-5-8-20-18(13-17)14-31(25(20)35)22-4-2-3-21(27-22)23-28-26-15-32(23)19-6-7-19/h2-5,8,13,15,19H,6-7,9-12,14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SEAL ROCK THERAPEUTICS, INC. US Patent					Assay Description Cryopreserved human PBMCs were obtained from AllCells (cat# PB003F). After thawing/dilution protocols using RPMI medium supplemented with 5% FBS (hea...				US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q27P91GS
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM307624 (5-(4- acetylpiperazine-1- carbonyl)-2-(6-(4- cyclo...) Show SMILES CC(=O)N1CCN(CC1)C(=O)c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C25H25N7O3/c1-16(33)29-9-11-30(12-10-29)24(34)17-5-8-20-18(13-17)14-31(25(20)35)22-4-2-3-21(27-22)23-28-26-15-32(23)19-6-7-19/h2-5,8,13,15,19H,6-7,9-12,14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
SEAL ROCK THERAPEUTICS, INC. US Patent					Assay Description Cryopreserved human PBMCs were obtained from AllCells (cat# PB003F). After thawing/dilution protocols using RPMI medium supplemented with 5% FBS (hea...				US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q2125VQ8
					More data for this Ligand-Target Pair