BDBM307639 5-amino-2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)isoindolin-1-one ::US10150755, Compound 31
SMILES: Nc1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1
InChI Key: InChIKey=LBLZBGDIGHABKE-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human)) | BDBM307639 (5-amino-2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SEAL ROCK THERAPEUTICS, INC. US Patent | Assay Description The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne... | US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q2125VQ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human)) | BDBM307639 (5-amino-2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <200 | n/a | n/a | n/a | n/a | n/a | n/a |
SEAL ROCK THERAPEUTICS, INC. US Patent | Assay Description The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne... | US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q27P91GS | |||||||||||
More data for this Ligand-Target Pair |