BDBM307655 6-(1-cyclopropyl- 1H-pyrazol-4-yl)-2- (6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridin-2- yl)isoindolin-1-one::US10150755, Compound 47

SMILES: O=C1N(Cc2ccc(cc12)-c1cnn(c1)C1CC1)c1cccc(n1)-c1nncn1C1CC1

InChI Key: InChIKey=RHRKCQIDEZCNDX-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307655   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM307655 (6-(1-cyclopropyl- 1H-pyrazol-4-yl)-2- (6-(4-cyclop...) Show SMILES O=C1N(Cc2ccc(cc12)-c1cnn(c1)C1CC1)c1cccc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C24H21N7O/c32-24-20-10-15(17-11-26-31(13-17)19-8-9-19)4-5-16(20)12-29(24)22-3-1-2-21(27-22)23-28-25-14-30(23)18-6-7-18/h1-5,10-11,13-14,18-19H,6-9,12H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SEAL ROCK THERAPEUTICS, INC. US Patent					Assay Description The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...				US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q2125VQ8
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM307655 (6-(1-cyclopropyl- 1H-pyrazol-4-yl)-2- (6-(4-cyclop...) Show SMILES O=C1N(Cc2ccc(cc12)-c1cnn(c1)C1CC1)c1cccc(n1)-c1nncn1C1CC1 Show InChI InChI=1S/C24H21N7O/c32-24-20-10-15(17-11-26-31(13-17)19-8-9-19)4-5-16(20)12-29(24)22-3-1-2-21(27-22)23-28-25-14-30(23)18-6-7-18/h1-5,10-11,13-14,18-19H,6-9,12H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<200	n/a	n/a	n/a	n/a	n/a	n/a
SEAL ROCK THERAPEUTICS, INC. US Patent					Assay Description The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...				US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q27P91GS
					More data for this Ligand-Target Pair