null

SMILES: COc1ccc(Nc2ncc(c(N[C@H]3CC[C@H](O)CC3)n2)-c2ccc(CN3CCCC3)cn2)cc1

InChI Key: InChIKey=ITRYMWSQXXWWJF-AQYVVDRMSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 308333   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM308333 (US9649309, Compound UNC4240A) Show SMILES COc1ccc(Nc2ncc(c(N[C@H]3CC[C@H](O)CC3)n2)-c2ccc(CN3CCCC3)cn2)cc1 |r,wU:13.12,wD:16.16,(-9.85,-1.54,;-8.52,-.77,;-7.19,-1.54,;-7.19,-3.08,;-5.85,-3.85,;-4.52,-3.08,;-3.19,-3.85,;-1.85,-3.08,;-.52,-3.85,;.82,-3.08,;.82,-1.54,;-.52,-.77,;-.52,.77,;-1.85,1.54,;-3.19,.77,;-4.52,1.54,;-4.52,3.08,;-5.85,3.85,;-3.19,3.85,;-1.85,3.08,;-1.85,-1.54,;2.15,-.77,;3.48,-1.54,;4.82,-.77,;4.82,.77,;6.15,1.54,;7.48,.77,;7.48,-.77,;8.95,-1.25,;9.85,,;8.95,1.25,;3.48,1.54,;2.15,.77,;-4.52,-1.54,;-5.85,-.77,)| Show InChI InChI=1S/C27H34N6O2/c1-35-23-11-7-21(8-12-23)31-27-29-17-24(26(32-27)30-20-5-9-22(34)10-6-20)25-13-4-19(16-28-25)18-33-14-2-3-15-33/h4,7-8,11-13,16-17,20,22,34H,2-3,5-6,9-10,14-15,18H2,1H3,(H2,29,30,31,32)/t20-,22-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
The University of North Carolina at Chapel Hill US Patent					Assay Description Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...				US Patent US9649309 (2017) BindingDB Entry DOI: 10.7270/Q26Q209H
					More data for this Ligand-Target Pair
Growth arrest-specific protein 6 (Homo sapiens (Human))	BDBM308333 (US9649309, Compound UNC4240A) Show SMILES COc1ccc(Nc2ncc(c(N[C@H]3CC[C@H](O)CC3)n2)-c2ccc(CN3CCCC3)cn2)cc1 |r,wU:13.12,wD:16.16,(-9.85,-1.54,;-8.52,-.77,;-7.19,-1.54,;-7.19,-3.08,;-5.85,-3.85,;-4.52,-3.08,;-3.19,-3.85,;-1.85,-3.08,;-.52,-3.85,;.82,-3.08,;.82,-1.54,;-.52,-.77,;-.52,.77,;-1.85,1.54,;-3.19,.77,;-4.52,1.54,;-4.52,3.08,;-5.85,3.85,;-3.19,3.85,;-1.85,3.08,;-1.85,-1.54,;2.15,-.77,;3.48,-1.54,;4.82,-.77,;4.82,.77,;6.15,1.54,;7.48,.77,;7.48,-.77,;8.95,-1.25,;9.85,,;8.95,1.25,;3.48,1.54,;2.15,.77,;-4.52,-1.54,;-5.85,-.77,)| Show InChI InChI=1S/C27H34N6O2/c1-35-23-11-7-21(8-12-23)31-27-29-17-24(26(32-27)30-20-5-9-22(34)10-6-20)25-13-4-19(16-28-25)18-33-14-2-3-15-33/h4,7-8,11-13,16-17,20,22,34H,2-3,5-6,9-10,14-15,18H2,1H3,(H2,29,30,31,32)/t20-,22-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
The University of North Carolina at Chapel Hill US Patent					Assay Description Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...				US Patent US9649309 (2017) BindingDB Entry DOI: 10.7270/Q26Q209H
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM308333 (US9649309, Compound UNC4240A) Show SMILES COc1ccc(Nc2ncc(c(N[C@H]3CC[C@H](O)CC3)n2)-c2ccc(CN3CCCC3)cn2)cc1 |r,wU:13.12,wD:16.16,(-9.85,-1.54,;-8.52,-.77,;-7.19,-1.54,;-7.19,-3.08,;-5.85,-3.85,;-4.52,-3.08,;-3.19,-3.85,;-1.85,-3.08,;-.52,-3.85,;.82,-3.08,;.82,-1.54,;-.52,-.77,;-.52,.77,;-1.85,1.54,;-3.19,.77,;-4.52,1.54,;-4.52,3.08,;-5.85,3.85,;-3.19,3.85,;-1.85,3.08,;-1.85,-1.54,;2.15,-.77,;3.48,-1.54,;4.82,-.77,;4.82,.77,;6.15,1.54,;7.48,.77,;7.48,-.77,;8.95,-1.25,;9.85,,;8.95,1.25,;3.48,1.54,;2.15,.77,;-4.52,-1.54,;-5.85,-.77,)| Show InChI InChI=1S/C27H34N6O2/c1-35-23-11-7-21(8-12-23)31-27-29-17-24(26(32-27)30-20-5-9-22(34)10-6-20)25-13-4-19(16-28-25)18-33-14-2-3-15-33/h4,7-8,11-13,16-17,20,22,34H,2-3,5-6,9-10,14-15,18H2,1H3,(H2,29,30,31,32)/t20-,22-	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
The University of North Carolina at Chapel Hill US Patent					Assay Description Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...				US Patent US9649309 (2017) BindingDB Entry DOI: 10.7270/Q26Q209H
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM308333 (US9649309, Compound UNC4240A) Show SMILES COc1ccc(Nc2ncc(c(N[C@H]3CC[C@H](O)CC3)n2)-c2ccc(CN3CCCC3)cn2)cc1 |r,wU:13.12,wD:16.16,(-9.85,-1.54,;-8.52,-.77,;-7.19,-1.54,;-7.19,-3.08,;-5.85,-3.85,;-4.52,-3.08,;-3.19,-3.85,;-1.85,-3.08,;-.52,-3.85,;.82,-3.08,;.82,-1.54,;-.52,-.77,;-.52,.77,;-1.85,1.54,;-3.19,.77,;-4.52,1.54,;-4.52,3.08,;-5.85,3.85,;-3.19,3.85,;-1.85,3.08,;-1.85,-1.54,;2.15,-.77,;3.48,-1.54,;4.82,-.77,;4.82,.77,;6.15,1.54,;7.48,.77,;7.48,-.77,;8.95,-1.25,;9.85,,;8.95,1.25,;3.48,1.54,;2.15,.77,;-4.52,-1.54,;-5.85,-.77,)| Show InChI InChI=1S/C27H34N6O2/c1-35-23-11-7-21(8-12-23)31-27-29-17-24(26(32-27)30-20-5-9-22(34)10-6-20)25-13-4-19(16-28-25)18-33-14-2-3-15-33/h4,7-8,11-13,16-17,20,22,34H,2-3,5-6,9-10,14-15,18H2,1H3,(H2,29,30,31,32)/t20-,22-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
The University of North Carolina at Chapel Hill US Patent					Assay Description Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ...				US Patent US9649309 (2017) BindingDB Entry DOI: 10.7270/Q26Q209H
					More data for this Ligand-Target Pair