Found 4 hits for monomerid = 308351 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM308351
(US9649309, Compound UNC4167A)Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CN2C3CCC2CC3)cn1 |r,wU:11.10,wD:14.14,THB:23:24:30.29:26.27,(-9.63,-3.85,;-8.29,-3.08,;-6.96,-3.85,;-5.63,-3.08,;-4.29,-3.85,;-2.96,-3.08,;-1.63,-3.85,;-.29,-3.08,;-.29,-1.54,;-1.63,-.77,;-1.63,.77,;-2.96,1.54,;-4.29,.77,;-5.63,1.54,;-5.63,3.08,;-6.96,3.85,;-4.29,3.85,;-2.96,3.08,;-2.96,-1.54,;1.04,-.77,;2.37,-1.54,;3.71,-.77,;3.71,.77,;5.04,1.54,;6.38,.77,;8.87,2.01,;9.63,.92,;8.09,.92,;7.33,2.01,;7.33,3.5,;8.87,3.5,;2.37,1.54,;1.04,.77,)| Show InChI InChI=1S/C26H38N6O/c1-2-3-14-27-26-29-16-23(25(31-26)30-19-5-11-22(33)12-6-19)24-13-4-18(15-28-24)17-32-20-7-8-21(32)10-9-20/h4,13,15-16,19-22,33H,2-3,5-12,14,17H2,1H3,(H2,27,29,30,31)/t19-,20?,21?,22- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.860 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ... |
US Patent US9649309 (2017)
BindingDB Entry DOI: 10.7270/Q26Q209H |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM308351
(US9649309, Compound UNC4167A)Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CN2C3CCC2CC3)cn1 |r,wU:11.10,wD:14.14,THB:23:24:30.29:26.27,(-9.63,-3.85,;-8.29,-3.08,;-6.96,-3.85,;-5.63,-3.08,;-4.29,-3.85,;-2.96,-3.08,;-1.63,-3.85,;-.29,-3.08,;-.29,-1.54,;-1.63,-.77,;-1.63,.77,;-2.96,1.54,;-4.29,.77,;-5.63,1.54,;-5.63,3.08,;-6.96,3.85,;-4.29,3.85,;-2.96,3.08,;-2.96,-1.54,;1.04,-.77,;2.37,-1.54,;3.71,-.77,;3.71,.77,;5.04,1.54,;6.38,.77,;8.87,2.01,;9.63,.92,;8.09,.92,;7.33,2.01,;7.33,3.5,;8.87,3.5,;2.37,1.54,;1.04,.77,)| Show InChI InChI=1S/C26H38N6O/c1-2-3-14-27-26-29-16-23(25(31-26)30-19-5-11-22(33)12-6-19)24-13-4-18(15-28-24)17-32-20-7-8-21(32)10-9-20/h4,13,15-16,19-22,33H,2-3,5-12,14,17H2,1H3,(H2,27,29,30,31)/t19-,20?,21?,22- | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ... |
US Patent US9649309 (2017)
BindingDB Entry DOI: 10.7270/Q26Q209H |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human)) | BDBM308351
(US9649309, Compound UNC4167A)Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CN2C3CCC2CC3)cn1 |r,wU:11.10,wD:14.14,THB:23:24:30.29:26.27,(-9.63,-3.85,;-8.29,-3.08,;-6.96,-3.85,;-5.63,-3.08,;-4.29,-3.85,;-2.96,-3.08,;-1.63,-3.85,;-.29,-3.08,;-.29,-1.54,;-1.63,-.77,;-1.63,.77,;-2.96,1.54,;-4.29,.77,;-5.63,1.54,;-5.63,3.08,;-6.96,3.85,;-4.29,3.85,;-2.96,3.08,;-2.96,-1.54,;1.04,-.77,;2.37,-1.54,;3.71,-.77,;3.71,.77,;5.04,1.54,;6.38,.77,;8.87,2.01,;9.63,.92,;8.09,.92,;7.33,2.01,;7.33,3.5,;8.87,3.5,;2.37,1.54,;1.04,.77,)| Show InChI InChI=1S/C26H38N6O/c1-2-3-14-27-26-29-16-23(25(31-26)30-19-5-11-22(33)12-6-19)24-13-4-18(15-28-24)17-32-20-7-8-21(32)10-9-20/h4,13,15-16,19-22,33H,2-3,5-12,14,17H2,1H3,(H2,27,29,30,31)/t19-,20?,21?,22- | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ... |
US Patent US9649309 (2017)
BindingDB Entry DOI: 10.7270/Q26Q209H |
More data for this Ligand-Target Pair | |
Growth arrest-specific protein 6
(Homo sapiens (Human)) | BDBM308351
(US9649309, Compound UNC4167A)Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CN2C3CCC2CC3)cn1 |r,wU:11.10,wD:14.14,THB:23:24:30.29:26.27,(-9.63,-3.85,;-8.29,-3.08,;-6.96,-3.85,;-5.63,-3.08,;-4.29,-3.85,;-2.96,-3.08,;-1.63,-3.85,;-.29,-3.08,;-.29,-1.54,;-1.63,-.77,;-1.63,.77,;-2.96,1.54,;-4.29,.77,;-5.63,1.54,;-5.63,3.08,;-6.96,3.85,;-4.29,3.85,;-2.96,3.08,;-2.96,-1.54,;1.04,-.77,;2.37,-1.54,;3.71,-.77,;3.71,.77,;5.04,1.54,;6.38,.77,;8.87,2.01,;9.63,.92,;8.09,.92,;7.33,2.01,;7.33,3.5,;8.87,3.5,;2.37,1.54,;1.04,.77,)| Show InChI InChI=1S/C26H38N6O/c1-2-3-14-27-26-29-16-23(25(31-26)30-19-5-11-22(33)12-6-19)24-13-4-18(15-28-24)17-32-20-7-8-21(32)10-9-20/h4,13,15-16,19-22,33H,2-3,5-12,14,17H2,1H3,(H2,27,29,30,31)/t19-,20?,21?,22- | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of North Carolina at Chapel Hill
US Patent
| Assay Description Briefly, activity assays were performed in a 384 well, polypropylene microplate in a final volume of 50 μL of 50 mM Hepes, Ph 7.4 containing 10 ... |
US Patent US9649309 (2017)
BindingDB Entry DOI: 10.7270/Q26Q209H |
More data for this Ligand-Target Pair | |