BindingDB PrimarySearch

BDBM30993 Ajmalicine::MLS000111555::Raubasine::SMR000107477::cid_251561

SMILES: COC(=O)C1=COC(C)C2CN3CCc4c([nH]c5ccccc45)C3CC12

InChI Key: InChIKey=GRTOGORTSDXSFK-UHFFFAOYSA-N

Data: 19 KI 1 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 30993
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
ADRA2C (OK)	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									J Pharmacol Exp Ther 259: 323-9 (1991) BindingDB Entry DOI: 10.7270/Q2Z899WV
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	0.660	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									J Pharmacol Exp Ther 259: 323-9 (1991) BindingDB Entry DOI: 10.7270/Q2Z899WV
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
ADRA2C (OK)	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									J Pharmacol Exp Ther 259: 323-9 (1991) BindingDB Entry DOI: 10.7270/Q2Z899WV
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (NEONATAL RAT)	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									J Pharmacol Exp Ther 259: 323-9 (1991) BindingDB Entry DOI: 10.7270/Q2Z899WV
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
ADRA2C (OK)	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	1.71	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									Mol Pharmacol 42: 1-5 (1992) BindingDB Entry DOI: 10.7270/Q2WH2NGR
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									Mol Pharmacol 42: 1-5 (1992) BindingDB Entry DOI: 10.7270/Q2WH2NGR
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									Mol Pharmacol 42: 1-5 (1992) BindingDB Entry DOI: 10.7270/Q2WH2NGR
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	8.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									J Pharmacol Exp Ther 259: 323-9 (1991) BindingDB Entry DOI: 10.7270/Q2Z899WV
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	8.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									Mol Pharmacol 42: 1-5 (1992) BindingDB Entry DOI: 10.7270/Q2WH2NGR
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
adrenergic Alpha2 (PIG)	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	Reactome pathway KEGG GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									J Pharmacol Exp Ther 271: 735-40 (1994) BindingDB Entry DOI: 10.7270/Q2VD6X0Z
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-2B adrenergic receptor (Homo sapiens (Human))	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	14.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									Mol Pharmacol 42: 1-5 (1992) BindingDB Entry DOI: 10.7270/Q2WH2NGR
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (NEONATAL RAT)	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	31.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									Mol Pharmacol 42: 1-5 (1992) BindingDB Entry DOI: 10.7270/Q2WH2NGR
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (NEONATAL RAT)	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									J Pharmacol Exp Ther 259: 323-9 (1991) BindingDB Entry DOI: 10.7270/Q2Z899WV
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	47.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo SmithKline Pharmaceuticals Curated by PDSP K_i Database									J Pharmacol Exp Ther 298: 219-25 (2001) BindingDB Entry DOI: 10.7270/Q2MS3R9D
					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Rattus norvegicus (rat))	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	289	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									J Pharmacol Exp Ther 271: 735-40 (1994) BindingDB Entry DOI: 10.7270/Q2VD6X0Z
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
adrenergic Alpha2 (RABBIT)	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	376	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo SmithKline Pharmaceuticals Curated by PDSP K_i Database									J Pharmacol Exp Ther 298: 219-25 (2001) BindingDB Entry DOI: 10.7270/Q2MS3R9D
					More data for this Ligand-Target Pair
adrenergic Alpha2 (RABBIT)	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	429	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo SmithKline Pharmaceuticals Curated by PDSP K_i Database									J Pharmacol Exp Ther 298: 219-25 (2001) BindingDB Entry DOI: 10.7270/Q2MS3R9D
					More data for this Ligand-Target Pair
adrenergic Alpha2 (BOVINE)	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	KEGG GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	653	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Curated by PDSP K_i Database									J Pharmacol Exp Ther 271: 735-40 (1994) BindingDB Entry DOI: 10.7270/Q2VD6X0Z
University of Nebraska Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Rattus norvegicus (rat))	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PubMed	1.47E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo SmithKline Pharmaceuticals Curated by PDSP K_i Database									J Pharmacol Exp Ther 298: 219-25 (2001) BindingDB Entry DOI: 10.7270/Q2MS3R9D
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM30993 (Ajmalicine \| MLS000111555 \| Raubasine \| SMR0001074...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	9.90E+4	n/a	n/a	7.4	23
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...				PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q21N7ZG0
					More data for this Ligand-Target Pair