BDBM310189 4-(3-chlorophenyl)-1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)piperazin-2-one::US10150758, Compound 5
SMILES: OC(CN1CCc2ccccc2C1)CN1CCN(CC1=O)c1cccc(Cl)c1
InChI Key: InChIKey=MNYWSKLJFHPLPG-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM310189 (4-(3-chlorophenyl)-1-(3-(3,4-dihydroisoquinolin-2(...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use.... | US Patent US10150758 (2018) BindingDB Entry DOI: 10.7270/Q2W95C8T | |||||||||||
More data for this Ligand-Target Pair |