BDBM310189 4-(3-chlorophenyl)-1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)piperazin-2-one::US10150758, Compound 5

SMILES: OC(CN1CCc2ccccc2C1)CN1CCN(CC1=O)c1cccc(Cl)c1

InChI Key: InChIKey=MNYWSKLJFHPLPG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 310189   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM310189 (4-(3-chlorophenyl)-1-(3-(3,4-dihydroisoquinolin-2(...) Show SMILES OC(CN1CCc2ccccc2C1)CN1CCN(CC1=O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H26ClN3O2/c23-19-6-3-7-20(12-19)25-10-11-26(22(28)16-25)15-21(27)14-24-9-8-17-4-1-2-5-18(17)13-24/h1-7,12,21,27H,8-11,13-16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US10150758 (2018) BindingDB Entry DOI: 10.7270/Q2W95C8T
					More data for this Ligand-Target Pair