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SMILES: C[C@@H](Oc1cc(cn2ncc(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1

InChI Key: InChIKey=GKSNOLIZSMVHCY-HUUCEWRRSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 311138   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK [342-635] (Homo sapiens (Human))	BDBM311138 (example 6.09 on page 559 of WO15017610) Show SMILES C[C@@H](Oc1cc(cn2ncc(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1 |r| Show InChI InChI=1S/C21H27N5O2/c1-13-8-23-25-11-16(17-10-24-26(12-17)21(3,4)5)6-18(20(13)25)28-14(2)15-7-19(27)22-9-15/h6,8,10-12,14-15H,7,9H2,1-5H3,(H,22,27)/t14-,15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human SYK (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag. The test compounds were dissolved in 100% D...				US Patent US10155751 (2018) BindingDB Entry DOI: 10.7270/Q2PK0J60
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [564-960] (Homo sapiens (Human))	BDBM311138 (example 6.09 on page 559 of WO15017610) Show SMILES C[C@@H](Oc1cc(cn2ncc(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1 |r| Show InChI InChI=1S/C21H27N5O2/c1-13-8-23-25-11-16(17-10-24-26(12-17)21(3,4)5)6-18(20(13)25)28-14(2)15-7-19(27)22-9-15/h6,8,10-12,14-15H,7,9H2,1-5H3,(H,22,27)/t14-,15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human FLT3 (amino acids 564-958, Molecular weight 48.6 kDa, Invitrogen #PR4666C) was expressed with an Histidine tag. The test compounds...				US Patent US10155751 (2018) BindingDB Entry DOI: 10.7270/Q2PK0J60
					More data for this Ligand-Target Pair
Aurora kinase B [1-341] (Homo sapiens (Human))	BDBM311138 (example 6.09 on page 559 of WO15017610) Show SMILES C[C@@H](Oc1cc(cn2ncc(C)c12)-c1cnn(c1)C(C)(C)C)[C@H]1CNC(=O)C1 |r| Show InChI InChI=1S/C21H27N5O2/c1-13-8-23-25-11-16(17-10-24-26(12-17)21(3,4)5)6-18(20(13)25)28-14(2)15-7-19(27)22-9-15/h6,8,10-12,14-15H,7,9H2,1-5H3,(H,22,27)/t14-,15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...				US Patent US10155751 (2018) BindingDB Entry DOI: 10.7270/Q2PK0J60
					More data for this Ligand-Target Pair