BDBM31139 5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11r
SMILES: Oc1cc2c(C(=O)OCc3ccccc3)c(Cc3ccc(Cl)cc3)[nH]c2c2ccccc12
InChI Key: InChIKey=MGYJZFAHYAJOGR-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Arachidonate 5-lipoxygenase (Homo sapiens (Human)) | BDBM31139 (5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11r) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 170 | n/a | 480 | n/a | n/a | n/a | n/a |
Friedrich Alexander University Erlangen | Assay Description For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated... | J Med Chem 52: 3474-83 (2009) Article DOI: 10.1021/jm900212y BindingDB Entry DOI: 10.7270/Q2HM56S5 | |||||||||||
More data for this Ligand-Target Pair |