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SMILES: COc1ccc(cc1)C(CNc1nn(C)c(=O)c2ccccc12)N(C)C

InChI Key: InChIKey=XHOSXDNEUKMRJB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 311431   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone acetyltransferase KAT2B [719-832]


(Homo sapiens (Human))		BDBM311431
PNG
(CHEM-US-00128 | US10155764, Example 21)
Show SMILES COc1ccc(cc1)C(CNc1nn(C)c(=O)c2ccccc12)N(C)C
Show InChI InChI=1S/C20H24N4O2/c1-23(2)18(14-9-11-15(26-4)12-10-14)13-21-19-16-7-5-6-8-17(16)20(25)24(3)22-19/h5-12,18H,13H2,1-4H3,(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 64n/an/an/an/an/an/a



GENENTECH, INC; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...

US Patent US10155764 (2018)


BindingDB Entry DOI: 10.7270/Q25M67T9
More data for this
Ligand-Target Pair